【摘要】 目的:观察高压氧联合胞磷胆碱钠和复方丹参治疗缺氧缺血性脑病的临床疗效。方法:将120例缺氧缺血性脑病(HIE)患儿随机分为3组,观察组(A)用高压氧联合胞磷胆碱钠和复方丹参注射液联合治疗,对照组(B、C)用高压氧和单一的药物治疗。结果:三组患儿临床神经系统症状、NBNA评分有显著性差异(P<0.01或P<0.05),三组HIE患儿各能区得分及治疗后发育商比较有明显的差异(P<0.05),从3个月头颅CT复查和神经系统后遗症发病率比较,观察组明显低于对照组(P<0.05)。结论:联合用药治疗HIE有协同作用,能减轻氧自由基引起的脑再灌注损伤,减少后遗症。此方法安全、经济、疗效确切。更多还原

【Abstract】 Objective: To investigate the clinical effects of hyperbaric oxygen therapy together with citicoline and salvia miltiorrhiza complex in neonates with hypoxic ischemic encephalopathy (HIE). Method: 120 neonates with HIE were randomly divided into 3 groups, the experimental group A (n=40) with combined therapy, the control group B (n=40) with traditional hyperbaric oxygen therapy and the control group C (n=40) with single drug therapy. Results: Compared with the control groups, the marks of NBNA, the scores of each capability district and growth quotient after therapy were significantly different (P<0.01, P<0.05) in the experiment group. The positive result of head CT examination in 3 month and sequelae of nervous system were also significantly lower (P<0.05) in experiment group, compared with the control group B and C. Conclusion: Combined therapy in neonates with HIE had cooperated effect, might relieve cerebral reperfusion damages and sequelae, improve population quality. The method was simple and had reliable cure effect.更多还原