【摘要】 目的　以阿昔洛韦 (acyclovir,ACV)为阳性对照 ,PBS以及含 10 %二甲亚砜 (DMSO)的PBS为阴性对照 ,观察了黄芪三种成分在活体中的抗人疱疹病毒Ⅰ型作用。方法　用HSV 1HS 1株感染豚鼠皮肤的动物模型 ,观察了黄芪总皂苷、总多糖、总黄酮抗HSV 1药效。结果　临床观察结果表明 :ACV ,黄芪总皂苷 ,总多糖 ,总黄酮处理皮区的累积计分依次为 ( 14 .2 0± 6 .70 ) ;( 12 .94± 3.0 1) ;( 12 .75± 3.5 8) ;( 15 .13± 5 .76 ) ;ACV ,黄芪总皂苷 ,总多糖 ,总黄酮处理皮区的痊愈天数分别为 ( 7.70±1.0 8) ;( 7.6 0± 2 .10 ) ;( 8.5 0± 0 .5 0 ) ;( 8.0 0± 0 .79) ,与PBS及含 10 %DMSO的PBS处理皮区有明显差异 ,并具有统计学意义。HSV 1HS 1株感染过程中各处理皮区的大体照片及皮肤样本的病理滴度检测得到了一致的结果。结论　配对T检验的结果表明 ,与黄芪总皂苷、总多糖、总黄酮处理皮区的累积计分、痊愈天数与ACV阳性对照组无显著差异。病毒滴度检测结果也如此。说明黄芪三种成分与ACV药效相近 ,值得开发利用。更多还原

【Abstract】 OBJECTIVE To investigate the antiherpes effects of three components from Astragalus membranaceus on human simplex virus type 1. METHOD Guniea pigs infected with cutaneous herpes virus were applied to study the effects of total saponins, total polysaccharids, total flavonoids from Astragalus membranaceus . Acyclovir(ACV) was used as positive control, while PBS and PBS containing 10% DMSO were used as negative controls.RESULTS The cumulative scores of the regions dealt with ACV, total saponins, total polysaccharids, total flavonoids were(14.20±6.70),(12.94±3.01),(12.75±3.58)and(15.13±5.76) respectively. The healing days of the regions treated with ACV, total saponins, total polysaccharids, total flavonoids were (7.70±1.08),(7.60±2.10),(8.50±0.50)and(8.00±0.79), respectively, which had significantly difference with those of the negative controls. The same results were obtained from the pictures and measurements of virus titers of skin samples of each treatment region. The cumulative scores and healing days of total saponins, total polysaccharids, totalflavonoids had no markedly difference with those of ACV.CONCLUSION The effects of three components studied in the present paper are close to that of ACV.更多还原