【摘要】 目的观察黄芪对化学性血虚和失血性血虚动物模型的补血功效,探讨黄芪单用或组方补气生血的机制。方法应用环磷酰胺(CTX)+乙酰苯肼(APH)引起大鼠骨髓造血系统抑制性损伤,并用放血法造成大、小鼠实验性失血模型。将60只8周龄SD大鼠单纯随机分成3组,观察黄芪分别在1,3.3,10g/(kg·d)×10d(小鼠)和0.7,2.3,7.6g/(kg·d)×14d(大鼠)三种剂量下对两种血虚模型造血功能的修复作用。结果黄芪能明显减轻CTX+APH引起的大鼠骨髓造血系统抑制性损伤,使化学性血虚大鼠、实验性失血小鼠的骨髓DNA含量、骨髓有核细胞(BMC)和外周血细胞(主要为红系)减少得以回升。结论动物实验证明黄芪具有升高外周血细胞、增强造血系统功能的作用。更多还原

【Abstract】 Aim To study effect of Astragalus membranaceus on enriching blood fun ction in animal models of chemical and hemorrhagic blood deficient.Methods Myelo suppression were induced by cyclophosphamide(CTX) and acelyphenylhydrazine(APH)i n rats;hemorrhagic blood deficient model was established by bleeding in mice.60 SD rats of 8 weeks old were randomly divided into 3 groups and the repair effect of Astragalus membranaceus at 1.1,3.3,10 g/kg.d(mice),0.7,2.3,7.6 g/kg.d(rats) in animal models of chemical and hemorrhagic blood deficientcy were observed.Res ults Astragalus membranaceus could significantly alleviate myelosuppression indu ced by CTX and APH in rats and elevate the level of peripheral blood cell(mainly red blood cells), DNA and nucleated cells in bone marrow in animal models of ch emical and hemorrhagic blood deficiency. Conclusion Astragalus membranaceus have the functions of strengthening spleen, supplementing Qi, accelerating hematopoi esis and increasing peripheral blood cell.更多还原