【摘要】 目的为了解高血压病合并糖尿病患者心率变异性与自主神经功能的关系,研究2型糖尿病(2型DM)合并原发性高血压(EH)与单纯2型DM、单纯EH对心率变异性(HRV)的影响。方法对86例2型DM或EH患者(其中30例2型DM合并EH,28例为单纯2型DM,28例单纯EH),进行24hHRV时域及频域分析。同时与年龄、性别相当的20例健康成年人HRV资料比较。结果(1)单纯EH患者与对照组比较,代表心率总变异程度的全部正常R-R间期的标准差(SDNN)犤(116±23)ms与(140±17)ms,P<0.05犦、每5minR-R间期均值的标准差(SDANN)犤(110±21)ms与(131±22)ms,P<0.05犦和SDNN的均值(SDNNI)犤(46±10)ms与(60±14)ms,P<0.05犦明显下降;代表迷走神经功能的正常相邻R-R间期差值的均方根(rMSSD)犤(23±6)ms与(39±10)ms,P<0.05犦和正常相邻R-R间期差值>50ms的百分比(PNN50)犤(4.4±1.9)%与(9.6±3.6)%,P<0.05犦也有下降;频域指标VLF升高犤(731±226)Hz与(440±237)Hz,P<0.05),HF犤(351±36)Hz与(744±72)Hz,P<0.05犦和LF犤(764±126)Hz与(963±156)Hz,P<0.05犦明显下降。(2)单纯DM患者与对照组比较,SDNN犤(110±22)ms与(140±17)ms,P<0.05犦,SDANN犤(106±20)ms与(131±22)ms,P<0.05犦和SDNNI犤(44±11)ms与(60±14)ms,P<0.05犦明显下降;rMSSD犤(22±6)ms与(39更多还原

【Abstract】 Aim To study effect of heart rate variability (HRV) in diabetes mellitus(DM) complicated with essential hypertension (EH) only DM and only EH.Methods 86 patients with DM and EH (included 30 patients DM complicated with EH, 28 patients only DM patients, 28 patients only EH) and 20 healthy controls were imvolved in the study HRV (included 24 h time domain and 24 h frequency domain) were measured to assess in DM patients. Results (1) Effects of only EH patients and normal healthy people: standard deviation of normal RR intervals(SDNN)[(116± 23)ms vs(140± 17)ms,P< 0.05],5 minutes standard deviation of NN interval(SDANN) [(110± 21)ms vs(131± 22)ms, P< 0.05]and standard deviation of normal RR intervals index(SDNNI)[(46± 10)ms vs(60± 14)ms,P< 0.05] and were decreased, root mean standard deviation of successive(rMSSD) [(23± 6)ms vs(39± 10)ms,P< 0.05] and percentage NN interval deviation greater than 50 ms(PNN50)[(4.4± 1.9)% vs(9.6± 3.6)% ,P< 0.05] were decreased.In associaion with the increases in VLF [(731± 226)Hz vs(440± 237)Hz, P< 0.05] were increased, LF [(764± 126)Hz vs(963± 156)Hz, P< 0.05] and HF [(351± 36)Hz vs(744± 72)Hz,P< 0.05] were decreased. (2) Effects of only DM patients and normal healthy pepole: SDNN [(110± 22)ms vs(140± 17)ms,P< 0.05], SDANN [(106± 20)ms vs(131± 22)ms, P< 0.05] and SDNNI [(44± 11)ms vs(60± 14)ms,P< 0.05] and were decreased, rMSSD [(22± 6)ms vs(39± 10)ms,P< 0.05] and PNN50 [(4.2± 1.6)% vs(9.6± 3.6)% ,P< 0.05] were decreased.In associaion with the increases in VLF [(716± 256)Hz vs(440± 237)Hz,P< 0.05] were increased, LF [(744± 121)Hz vs(963± 156)Hz,P< 0.05] and HF[(320± 48)Hz vs(744± 72)Hz,P< 0.05] were decreased. (3)Effects of DM complicated with EH patients and only DM patients and only EH patients: SDNN [(96± 18)ms vs(110± 22)ms,(116± 23)ms, P< 0.01], SDANN [(86± 16)ms vs(106± 20)ms,(110± 21)ms,P< 0.01] and SDNNI [(30± 10)ms vs(44± 11)ms,(46± 10)ms, P< 0.01] and were decreased, rMSSD [(15± 7)ms vs(22± 6)ms, (23± 6)ms,P< 0.01] and PNN50 [(2.4± 1.2)% vs(4.2± 1.6)% ,(4.4± 1.9)% ,P< 0.01] were decreased. In associaion with the increases in VLF [(1236± 366)Hz vs (716± 256)Hz, (731± 226)Hz, P< 0.05] were increased, LF [(544± 108)Hz vs(744± 121)Hz,(764± 126)Hz, P< 0.05] and HF [(169± 25)Hz vs(320± 48)Hz,(351± 36)Hz,P< 0.05].Conclusion HRV may be helpful to predictors for severify of cardiac fundiac function in DM and EH.<P>更多还原