【摘要】 目的:观察山东地区类风湿关节炎(RA)发病及其临床表现与人类白细胞相关抗原(HLA)-DR1,DR4、DR10等位基因频率的关系。方法:特异性引物聚合酶链式反应(PCR-SSP)方法分别测定132例RA患者及130例正常人的HLA-DR1,DR4、DR10的基因频率。结果:3种基因在132例RA患者中基因频率分别为9.8%、46.2%、11.4%,而在正常对照组的相应基因频率分别为5.4%、19.2%、6.9%,其中HLA-DR4较正常对照有统计学意义,HLA-DR1,DR10则无统计学意义。结论:山东地区RA易感性与共同表位(SE)有关,其中主要和HLA-DR4关联密切。HLA-DR1,DR10不是RA易感基因。更多还原

【Abstract】 Objective:To investigate the correlation of the pathogenesis and clinical manifestations of rheuma toid arthritis with the gene frequencies of HLA-DR1,DR4,and DR10alleles.Methods :132RA patients and130healthy subjects were examined separately with PCR-SSP to get the gene frequencies of the three alleles.Results:The gene frequencies of HLA-DR1,DR4and DR10in the RA patients were9.8%,46.2%and11.4%and5.4%,19.2%and6.9%in the control group,re spec tively.The gene fre quen cy of HLA-DR4alle les in RA patients was higher than in the normal subjects(P<0.0001)but the dif ference of the gene fre quencies of HLA-DR1and HLA-DR10between the two groups was of no signifi cance.Con clu sion:The study suggests that the SE gene is the risk fac tor of RA in the population of Han na-tion ality in Shan dong area and the suscep ti bility to RA is related with HLA-DR4rather than HLA-DR1and HLA-DR10.更多还原