【摘要】 目的　了解淋病奈瑟菌的耐药性及β -内酰胺酶的产生情况。方法　对门诊 1998～ 2 0 0 1年分离的 60 2株淋病奈瑟菌进行 14种抗菌药物的耐药性分析 ,同时检测β -内酰胺酶。结果　药敏试验结果显示 :头孢噻肟 (Cefo taxime,CTX)和原始霉素 (Pristinomycin ,PRI)的耐药率分别为 4 65 %和 4 98% ,而甲氧苄氨嘧啶 (Trimethoprim ,TMP)的耐药率为 94 5 2 %。 60 2株淋病奈瑟菌中产β-内酰胺酶淋病奈瑟菌 (PPNG)占 3 8 87% ,抗四环素淋病奈瑟菌 (TRNG)占 16 44 %。结论　头孢噻肟和原始霉素应作为本地区目前临床治疗淋病奈瑟菌感染的首选药物更多还原

【Abstract】 Objective To survey drug resistance and β-lactamase producing.Methods β-lactamase producing Ngonorrhoeae(PPNG) and the drug resistance of 14 antibiotics to 602 strains from 1998 to 2001 were determined respectively.Results The results showed the susceptibility of the isolates to cefotaxime and pristinomycin was highest(9535%,9502% respectively) and trimethoprim was lowest(316%).The drug resistance to trimethoprim was highest(9452%)and cefotaxime and pristinomycin was lowest(465%,498% respectively).3887% of 602 isolates NGonorrhoeae were PPNG,and 1644% were TRNG.Conclusion Cefotaxime and pristinomycin are drugs of first choice in treatment of Neisseria gonorrhoeae infection in this area.更多还原