【摘要】 目的　研究氯丙咪嗪与帕罗西汀治疗早泄的疗效和副作用。方法　选择符合DSM -Ⅳ早泄诊断标准的病人 80名 ,随机分为帕罗西汀和氯丙咪嗪两个治疗组 ,病人每天服用帕罗西汀 2 0mg或氯丙咪嗪 3 0mg ,4周后用自行编制的问卷评价治疗结果。结果　帕罗西汀组有 5个病人脱落 ,氯丙咪嗪组脱落 7个 ,两组之间在疗效和起效时间方面没有明显差异 ,氯丙咪嗪组副作用略多于帕罗西汀组。结论　两种药都可以用于治疗早泄 ,鉴于大剂量服用氯丙咪嗪有一定危险性 ,建议由有经验的医生使用更多还原

【Abstract】 Objective To study the efficacy of Paroxetine and clomipramine for treatment of premature ejaculation.Methods 80 male outpatients with premature ejaculation were randomly assigned to treat with Paroxetine (N=40) or clomipramine (N=40).Patients took paroxetine 20 mg/day or clomipramine 30 mg/day for 4 weeks.Results In Paroxetine group 35 patients finished the study finally and ejaculation latency (EL) increased from 1.99±0.99 min to 9.17±5.63 min.In clomipramine group 33 patients finished study and EL increased from 1.38±0.9 min to 11.80±12.52 min.No statistically significant differences were found between the two groups(t=1.129,df=66,P>0.05).Side effects of clomipramine group are slightly more than Paroxetine group.Conclusions Efficacy of Paroxetine and clomipramine are similar in treatment of premature ejaculation,but the Paroxetine is safer than the clomipramine.更多还原