【摘要】 目的　评价男性 2型糖尿病患者病程与骨密度和骨代谢指标的变化的关系。方法　同时测定2 4例正常人和 6 2例男性 2型糖尿病患者的骨密度 (BMD)、血骨钙素 (BGP)、骨型特异性碱性磷酸酶 (BAP)、Ⅰ型胶原氨基末端肽 (NTx)、甲状旁腺素 (PTH)、血钙、血磷和血浆白蛋白。根据病程将糖尿病分为Ⅰ组 :病程 <5年 ,31例 ;Ⅱ组 :病程 5～ 10年 ,2 0例 ;Ⅲ组 :病程 >10年 ,11例。结果　与正常对照组 (K组 )比较 ,Ⅰ组和Ⅱ组患者BMD、BGP、BAP、PTH和NTx差异无显著意义 (P >0 0 5 ) ;Ⅲ组糖尿病BMD明显下降 ,P <0 0 5 ;BGP、BAP、NTx和PTH显著增高 ,P <0 0 1。结论　病程 (大于 10年 )是男性 2型糖尿病患者骨质疏松症的重要危险因素。更多还原

【Abstract】 Objective To evaluate the changes of bone mineral density(BMD) and parameters of bone metabolism and their risk factors in males with type 2 diabetes mellitus.Methods BMD,serum osteocalcin(BGP),bone specific alkaline phosphatase(BAP),cross linked N telopeptides of type Ⅰ collagen(NTx),parathyroid hormone(PTH),calcium,phosphate,albumin were measured in 62 male patients with type 2 diabetes mellitus and 24 control subjects(group K).According to the diabetic course,62 patients were divided into group Ⅰ(course less than 5 years,n=31),group Ⅱ(course between 5 and 10 years,n=20) and group Ⅲ(course more than 10 years,n=11).Results Compared with group K,BMD,BGP,BAP,PTH and NTx had no significant changes in group Ⅰ and group Ⅱ,but BMD decreased significantly(P<0.05),and BGP,BAP,NTx and PTH increased markedly(P<0.01) in group Ⅲ.Conclusion Diabetic course(more than 10 years) is a important risk factor of osteoporosis associated with type 2 diabetes mellitus in male.更多还原