【摘要】 目的　探讨神经生长因子 (nervegrowthfactor ,NGF)及其受体 p75在宫颈原位癌中的表达及意义。 方法　采用免疫组织化学S P法检测宫颈鳞状上皮原位癌 30例、正常上皮组织 13例、中～重度不典型增生 13例和浸润癌 14例石蜡包埋组织中NGF和 p75的表达。 结果　NGF在宫颈鳞状上皮正常组、不典型增生组、原位癌组中的表达呈逐渐增高趋势 ,而浸润癌组的表达却下降 ,差异有显著性 (χ2 =9 90 6 ,P <0 0 5 ) ,正常组与不典型增生组、原位癌组相比差异均有显著性 (t =2 0 0 7,P<0 0 5 ;t=2 0 0 8,P <0 0 5 ) ,浸润癌组与不典型增生组、原位癌组相比差异均有显著性 (t =2 37,P <0 0 5 ;t =2 4 4 ,P <0 0 5 )。p75在宫颈鳞状上皮正常组、不典型增生组、原位癌组、浸润癌组中的表达呈逐渐降低趋势 ,其差异有显著性 (χ2 =18 5 6 8,P <0 0 1) ,浸润癌组与正常组、不典型增生组、原位癌组相比差异均有显著性 (t =2 5 6 ,P <0 0 5 ;t =2 5 6 ,P <0 0 5 ;t=2 6 5 ,P <0 0 5 )。结论　NGF的高表达是宫颈瘤变过程中的早期事件。p75与宫颈癌的恶性进展有关 ,p75表达减少在原位癌是维持现状还是进展为浸润癌过程中起着重要的作用更多还原

【Abstract】 Purpose To investigate expression of nerve growth factor (NGF) and its receptor (p75) in carcinoma in situ of cervix and its significance in studying mechanism of tumor development. Methods The expression of NGF and p75 proteins was detected by immunohistochemical S P method in paraffin sections of 70 cervical samples comparising 30 cases of squamous carcinoma in situ (SCIS), 13 normal squamous epithelium (NSE), 13 dysplasia squamous epithelial hyperplasia (DSEH) and 14 cases of invasive squamous epithelial carcinoma (ISEC) of cervix. Results Expression of NGF had a increasing trend in NSE,DSEH, and SCIS, but low expression was found in ISEC. The expression had significant difference between NSE and DSEH, ISEC and SCIS. Expression of p75 had a descreasing trend in NSE, DSEH, SCIS and ISEC. The expression had significant difference between ISEC, NSE, DSEH and SCIS respectively. Conclusions The high expression of NGF is an early event in progression of neoplasia of cervix. The low expression of p75 correlates with progress of malignant transformation and p75 plays an important role in deciding where the carcinoma in situ will go.更多还原