【摘要】 本文综述了国外近年开发的抗骨质疏松新药依普黄酮关键中间体7-羟基异黄酮的合成技术及其进展情况,并对其合成方法的优缺点进行了述评,指出以间苯二酚和苯乙酸为主要原料合成2,4-二羟基苯基苄酮,然后与原甲酸三乙酯环合的合成路线是较合适的工业化生产路线。更多还原

【Abstract】 Synthetic technique and development progress of 7 - hydroxyisoflavone, a key intermediate for synthesizing newly developed antiosteoporosis drug, are reviewed. The advantages and disadvantages of the synthetic methods are also discussed and it is pointed out that cyclocondensation of triethyl orthoformate with 2 ,4-dihydroxyphenyl benzyl ketone synthesized based on resorcinol and phenylacetic acid is an appropriate technology for commercial production of 7- hydroxyisoflavone.更多还原