【摘要】 目的　研究凝固酶阴性葡萄球菌 (CNS)院内感染的危险因素。方法　采用巢式病例 -对照研究 ,对 30例确诊为 CNS医院内感染的病例 ,按同科室、同性别、年龄相近 (± 5 a) ,入院时间相近(± 1周 ) ,病情相似 ,按 1∶ 1配对选择 30例对照 ,探讨 CNS医院内感染的危险因素。结果　对 14种可能的危险因素进行单因素分析 ,提示有 6种为可疑危险因素 ;对这 6种因素进一步进行条件logistic回归分析 ,结果表明 :使用头孢三代抗生素 >10 d(OR =15 .984 )、合并真菌感染 (OR =11.2 2 9)、大静脉插管 >10 d(OR =8.876 )、留置导尿 >7d(OR =7.0 93)为 CNS医院内感染的独立危险因素。结论　对有上述危险因素存在的患者 ,要严密观察有无感染发生 ,缩短头孢三代抗生素使用时间、减少大静脉插管和留置导尿管等侵入性操作时间、积极治疗真菌感染均能减少 CNS医院内感染的发生更多还原

【Abstract】 Objective To explore the risk factors of coagulase negative staphylococcus induced nosocomial infection. Methods A nested case control study was conducted among 30 patients with CNS induced nosocomial infection and other 30 control patients, they were matched by the ratio of 1 to 1 based on the same department, sex, diagnosis and similar age range less than 5 years old, time in hospital (less than 7 days). Results Four factors were significant among 14 factors: abuse of third generation cephalosporins (OR=15.984), merger with epiphyte infection (OR= 11.299 ), central vein catheter more than ten days (OR=8.876), indwelling urethral catheterization over seven days (OR=7.093). Conclusions The patients who exposed to the risk factors should be strictly monitored in order to find out infection in time.更多还原