【摘要】 目的　探索中国人Ⅱb型高脂蛋白血症患者低密度脂蛋白受体相关蛋白 (LRP)四核苷酸重复序列 (TTTC)n基因多态性与血清脂质、脂蛋白和载脂蛋白水平的关系。方法　采用聚合酶链反应结合聚丙烯酰胺凝胶电泳和银染技术 ,分别对 72例Ⅱb型高脂蛋白血症患者及 10 1例正常健康人的LRP(TTTC)n基因多态性进行基因型检测 ,同时对TG、TC、LDL C、HDL C、ApoA、ApoB浓度进行测定。结果　Ⅱb型高脂蛋白血症患者的TG、TC、LDL C、ApoB较正常对照组显著性升高 (P <0 .0 1) ;而且Ⅱb型高脂蛋白血症组TC、LDL C、ApoB由 5 / 5、5 / 6、向 6 / 6基因型变化中存在渐降趋势 ,且有统计学意义 (P <0 .0 1) ,而正常对照组也有类似的变化趋势 ,但无统计学意义 (P >0 .0 5 )。结论　Ⅱb型高脂蛋白血症患者LRP四核苷酸重复序列 (TTTC)n不同基因型与血脂水平有关更多还原

【Abstract】 Objective Tostudy LRP(TTTC)n geno type and itsrelation ship with serumlipids,lipoproteinsandapolipoproteinsinChinesepatientswithtypeⅡbhyperlipoproteinemia .Methods LRP (TTTC)ngenotypewereanalysedbypolymerasechainreatients(PCR)andhighvoltagepolyacryamiedgelelectrophesis.Thegelswerestainedbysilvernitrate.Serumlipidwerebyenztmemothodandapolipoprteinsweremeasuredbyradialimmunodiffusionin 10 1healthycontroland 72typeⅡbhyperlipoproteinemiapatients.Result ComparedwiththecontrolgroupthevaluesofserumTG、TCH、LDL C、ApoBinpatientswithtypeⅡbhyperlipoproteinemiawresignifi canylyincreased(P <0 0 1) .WithachangeoftypeⅡbhyperlipoproteinemiafrom 5 / 5and 5 / 6to 6 / 6 ,theconcentrationsofTC、LDL CandApoBtendeddownwardsgraduallyandhadstatisticallySignification .HoweverthehealthygroupalsohadsuchatendencybutdonotStatisticallysignificantion .Conclusion LRP(TTTC)ngenetypewasassociatedwithserumlipidlevelintypeⅡbhyperlipoproteinemia .更多还原