【摘要】 目的　探讨卡孕栓用于剖宫产预防产后出血的有效性和安全性。方法　剖宫产者 2 0 9例随机分为卡孕栓组 10 3例和对照组 10 6例 ,卡孕栓组在腹膜切开后舌下含服卡孕栓 1mg ,两组产妇在胎儿娩出后向子宫肌层注入催产素 2 0IU、对照组静脉滴注催产素 2 0IU。观察两组术中和产后 2 4h出血量及产后血红蛋白变化情况。结果　卡孕栓组术中和产后 2 4h平均出血量分别为191 2ml和 3 17 2ml ,对照组分别为 2 16 6ml和 3 5 0 5ml ,两组相比有显著性差异 (P <0 0 5 ) ,卡孕栓组术后血红蛋白减少量明显低于对照组 (P <0 0 1) ,卡孕栓组未出现明显副反应。结论　卡孕栓在剖宫产中促进子宫收缩明显 ,能较好地预防产后出血 ,舌下给药方便、安全、高效更多还原

【Abstract】 Objective To study the efficacy and safety of methylcarboprost suppository in preventing postpartum hemorrhage of cesarean section.Methods Two hundred and nine puerperants with cesarean section were randomly divided into two groups: test group(n=103),1mg methylcarboprost suppository was given sublingually after peritoneotomy,and control group(n=106),20IU oxytocin intravenous drip immediately after neonate delivery. 20IU oxytocin were injected into uterine muscularis in the both groups after neonate delivery.The amount of bleeding in perioperation and 24 hours after delivery were measured.Results The blood loss volumes in perioperation and 24hour after delivery in test group were 191 2ml and 317 2ml respectively, and in control group were 216 6ml and 350 5ml respectively,and there was significant difference in the blood loss volume between the two groups(P<0 05).The decrease of hemoglobin in test group was significantly less than that of control group(P<0 01). No obvious side effects were found in test group.Conclusions Methylcarboprost suppository is more effective than oxytocin in preventing postpartum hemorrhage in cesarean section. Sublingual administration of methylcarboprost suppository is a simple and efficient pathway.更多还原