【摘要】 目的　探讨δ阿片受体特异性拮抗剂ICI1 74 ,86 4对创伤失血性休克大鼠血流动力学指标的影响及其与垂体的关系。方法　复制大鼠创伤失血性休克模型 ,观察ICI1 74 ,86 4对血压 (MAP) ,左室内压 (LVSP) ,左室内压最大变化速率 (±dp/dt max)等血流动力学指标的影响及垂体摘除对ICI1 74 ,86 4作用的影响。结果　ICI1 74 ,86 4 (5 0mg,2 0ml)侧脑室给药可显著升高创伤失血性休克大鼠的MAP、LVSP、±dp/dtmax等血流动力学指标。垂体摘除可取消ICI1 74 ,86 4的上述作用。结论　δ阿片受体特异性拮抗剂ICI1 74 ,86 4对创伤失血性休克心血管功能指标有较好的的改善作用 ,ICI1 74 ,86 4的这一作用与垂体的完整性密切相关。更多还原

【Abstract】 Objective To investigate the effects of specific delta opioid receptor antagonist ICI174,864 on hemodynamic parameters following traumatic hemorrhagic shock in rats and its relationship with pituitary gland.Methods With a model of traumatic hemorrhagic shock rat, we observed the effects of IC174,864 on mean arterial pressure (MAP), left intraventricular systolic pressure (LCSP), the maximal change rate of left intraventricular pressure (±dp/dtmax), the maximal physiological velocity of cardiac contractile element shortening(Vpm), and the area of p dp/dt vector loop (Lo). Meanwhile the influence of hypophysectomy on effects of ICI174,864 was investigated. Results ICI174,864 , intracerebral ventricular administration, could significantly increase the hemodynamic parameters and cardiac contractility. Hypophysecttomy could abolish these actions of ICI174,864.Conclusion Specific delta opioid receptor antagonist ICI174,864 had beneficial effects on hemodynamics following traumatic hemorrhagic shock, this effect of ICI174,864 was closely related to the intact of pituitary gland.更多还原