【摘要】 目的探讨高血压脑出血患者急性期(AHCH) 血S-100蛋白含量变化及其与临床表现的关系。方法对56例高血压脑出血患者分别在24 h内和第3 d、第7 d进行血S-100蛋白定量测定,同时第3 d经腰穿测定颅内压(ICP)。50例“正常健康成人”进行血S-100蛋白定量测定作为对照组,并结合临床资料进行分析。结果高血压后7 d内血S-100蛋白含量显著高于正常对照组(P<0.001)。出血后24 h与7 d之间S-100蛋白水平无显著差异(P>0.05),24 h与3 d之间有显著差异(P<0.05),3 d与7 d之间血S-100蛋白含量无显著差异(P>0.05)。1个月后清醒组与非清醒组(包括死亡)之间血S-100蛋白水平有显著差异(P<0.05),56例患者ICP测得值与血S-100蛋白含量水平呈直线正相关(r=0.956,P<0.01)。结论高血压脑出血急性期血S-100蛋白含量显著升高,其能间接地预测病人的病情及脑损害程度,对预后的判断亦有指导意义。更多还原

【Abstract】 Objective The changes of serum S-100 protein levels in patients with acute hypertensive cerebral hemorrhage (AHCH) and the relationship to the clinical characters were studied . Methods56 patients with AHCH were performed with the measures of serum S-100 protein during 24 hour , the 3rd day and 7th , and ICP were measured during 3 days after attack. 50 "normal healthy adults"were performed with the measures of S-100 protein . Results The serum S-100 protein levels in patients with AHCH were still higher than normal control group during 7 days (P<0.001) . There was nonsignificant difference among those in the 24th hour and in 7th day (P>0.05) . There was significant difference among those in the 24th hour and in the 3rd day (P<0.05) , and there was nonsignificant difference among those in the 3rd and in 7th day (P>0.05) . The serum S-100 protein levels between clear-headed group and non-clear-headed group in one month had significant difference (P<0.05). The relationship between ICP levels of 56 patients and the serum S-100 protein levels was linear positive correlation. r=0.956 (P<0.01) . Conclusion The S-100 protein levels in patients with AHCH was risen obviously , they can be used in the valuation for the state of patients and degree of brain damage , and prognose the outcome of patients indirectly .更多还原