【摘要】 目的　研究直肠癌患者术前直肠黏膜下植入 5 Fu缓释剂后 ,药物在局部的分布、扩散情况。方法　对 13例直肠癌拟手术患者术前直肠黏膜下植入 5 Fu缓释剂 5 0 0mg ,72h后手术 ,术中抽取肠系膜下静脉血和外周静脉血 ,并取癌组织癌旁近端的肠壁组织 ,用高效液相色谱法检测 5 Fu浓度。实验数据采用SPSSl0软件进行统计学处理。结果　肠系膜下静脉血 5 Fu浓度显著高于同时相外周血浓度 ,癌组织 5 Fu浓度显著高于癌旁组织浓度 ,全组未发现全身及局部毒副作用。结论　直肠黏膜下植入 5 Fu缓释剂是直肠癌术前区域性化疗的最佳途径之一 ;证实了区域性化疗局部 5 Fu高浓度的优势 ,可望提高直肠癌根治术后的远期疗效更多还原

【Abstract】 AIM In order to evaluate the effect of a neoadjuvantchemotherapy with 5 Fluorouracil sustained release for implant(5 Fu SRI)injected in rectal submucosa in the patients with rectal cancer.The effect of this treatment was judged by 5 Fu concentration in blood and tissue. METHODS 13 patients with rectal cancer underwent the treatment of submucosal multiple 5 Fu SRI with the simple dose of 500 mg before 72 hours of operation.The level of 5 Fu in peripheral veins,inferior mesenteric veins and in the tissues of tumor and para tumor was studied. 5 Fu was detected by high performance liquid chromatography (HPLC). The program of SPSS(10) was used.Data were presented as means±standard deviation(SD). RESULTS The concentration of 5 Fu in peripleral veins, inferior mesenteric veins,tumor tissues and pera tumor tissues at 72 h were (0 219±0 162),(0 418±0 261),(1 478±1 333) and (0 646±0 600) mg·kg -1 respectively.NO side effect was found in all patients.CONCLUSION The treatment of rectal submucosal multiple implant of 5 FuSRl presents a significant local high 5 Fu concentration advantage and reasonability in preventing post operative recurrence,metastasis of rectal cancer.更多还原