【摘要】 目的　探讨血清透明质酸 (HA)及层粘连蛋白与矽肺病情之间的关系。方法　用放免法测定 149例诊断的矽肺患者和同厂 87例不接触矽尘工人作对照组的血清HA及LN含量 ,分析病例组和对照组间关系。结果　病例组血清HA平均水平 2 2 9.46± 32 .2 79ng/ml,特别是Ⅲ期矽肺患者血清HA含量为 2 72 .71±2 0 4.6 5ng/ml,显著高于对照组 172 .31± 12 0 .18ng/ml(P <0 .0 5 ) ;而LN则相反 ,病例组血清含量为 144 .11ng/ml,较对照组 2 46 .44ng/ml为低 (P <0 .0 0 1)。 结论　测定尘肺患者血清HA和LN含量可能对病情监测有一定参考值。更多还原

【Abstract】 Objective to study the relationship between serum hyaluronate (HA), Laminin (LN) levels and silicosis. Methods levels of serum HA and LN were measured in 149 silicosis and 87 workers without silicon in the same factory by using radioimmunoassay. Results The mean level of HA in silicosis was 229.46ng/ml, and the mean level of HA in stage Ⅲ silicosis was 272.71ng/ml, which were much higher than that in the control group 172.31ng/ml. (P<0.05) On the contrary, the mean level of LN in silicosis groups were 144.11ng/ml, which was lower than that in the control group 246.44ng/ml. (P<0.001). Conclusions The levels of serum HA and LN in silicosis might be of certain value to monitor the patients condition.更多还原