【摘要】 目的　探讨 2 ,4 -D异辛酯的亚慢性经口毒性效应 ,且取得最大无作用剂量参数 ,为慢性毒性试验提供接触剂量参考数据及观测指标。方法　选取健康Wistar大鼠 96只 ,随机分为高、中、低、对照 4个组 ;试验 3个月结束时 ,断头处死观测相关指标。结果　高剂量组使雌性大鼠ALT含量升高 ,使雌、雄性大鼠ChE活力降低 ,与对照组比较均具有极显著意义 (P <0 0 1) ,且呈剂量效应关系。结论　 2 ,4 -D异辛酯为低毒类农药 ;大鼠喂饲 ,2 ,4 -D异辛酯 3个月最大无作用剂量为 6mg/kg d ,以 10 0倍安全系数计 ,其日容许摄入量为 0 0 6mg/kg更多还原

【Abstract】 Objective Study of experiment of subchronic oral toxcity of 2,4-D Isooctyl Ester in rat.Methods 96 healthy Wistar rats were randomly divided into four groups according to the dose:low,middle,high and a control group.three months later killed them by ecollation and determined the related indexes.Results Contents of ALT of the female rats in high group were increased,and compared with the control,the change was highly significant (P<0 01) Compared with the control,the activities of ChE in high group were significantly decreased than that in control group(P<0 01)with a dose dependent response.Conclusion 2,4-D Isooctyl Ester was graded as low toxicity;the maximal no-effect dose of 2,4-D Isooctyl Ester feed on the rats for 3 months is 6mg/kg.d,if the coefficient of safe is chosen as 100,ADI is 0.06mg/kg.更多还原