【摘要】 目的:研究太白参提取物对小鼠氧化损伤的保护作用及其活性部位。方法:以太白参总提物、正丁醇部位和水溶部位分别按生药15 g·kg^-1·d^-1对小鼠灌胃给药,腹腔注射四氧嘧啶180 mg·kg^-1制造小鼠氧化损伤模型,测定红细胞和肝脏的SOD、GSH-P_x、LPO,血清ALT、AST、和AKP,脑LPO和MAO-B,肝指数和脾指数。结果:太白参的三种提取物均可显著降低四氧嘧啶引起的SOD、GSH-Px、LPO、ALT、AST、AKP和MAO-B的异常增高,抑制肝指数、脾指数的下降。结论:太白参提取物对小鼠的抗氧化损伤有保护作用,总提物与正丁醇部位的抗氧化作用优于水溶部位。更多还原

【Abstract】 Objective:To study the protection effects of Pedicalaris decorm extract on oxidation lesion in mice and the effective components of Pedicalaris decorm. Methods:The total extract,BuOH soluble components and water soluble components of Pedicalaris decorm were administered (ig) 15 g.kg-1.d-1 to mice,and the oxidation injury model in mice was induced by ip alloxan 180 mg.kg-1.SOD,GSH-Px and LPO in red blood cell and liver,ALT,AST,AKP and r-globulin in serum,LPO and MAO’B in brain,liver index and spleen index were measured. Results:All the three Pedicalaris decorm extracts can obviously lower abnormal contents of SOD,GSH-Px,LPO,ALT,AST,AKP,MAO.B and r-globulin induced by alloxa,and obviously improve abnormal decrease of liver index and spleen index. Conclusion: Pedicalaris decorm extract can inhibit oxidation lesion in mice. The effects of total extract and BuOH soluble components were better than water soluble components.更多还原