【摘要】 目的 :比较替卡西林 克拉维酸和头孢他啶治疗中重度感染的疗效及安全性。方法 :采用前瞻性随机、开放、对照试验 ,治疗组 2 1例用替卡西林 克拉维酸 3.2g ,q8h ,iv ;对照组 2 0例 ,用头孢他啶 1g ,q8h ,iv ,2组疗程为 3～ 14d。结果 :治疗组和对照组临床治疗总有效率分别为 76 % (16 2 1)和 6 5 % (13 2 0 ) ,无统计学差异 (P >0 .0 5 ) ;细菌学清除率分别为 71% (15 2 1)和 5 5 % (11 2 0 ) ;不良反应发生率分别为 14 % (3 2 1)和 5 % (1 2 0 )。结论 :替卡西林 克拉维酸治疗中重度感染时疗效和不良反应与头孢他啶相似。更多还原

【Abstract】 Objective:To compare the clinical efficacy and safety profile of ticarcillin/clavulanic acid and ceftazidime in treatment of moderate and severe infection.Methods:A total of 41 patients were enrolled in this prospective,randomized,open,controlled study.They were divided into two groups,the test group( n =21) received ticarcillin/clavulanic acid (3.2g,q8h,iv) and the control group( n =20) recieved ceftazidime(1g,q8h,iv) for 3～14 days.Results:The clinical response rates,bacteriologic eradication rates,and adverse reaction rates were similar in the test group (76%,71% and 14%,respectively) and the control group (65%, 55% and 5%, respectively).Conclusion:Ticarcillin/clavulanic acid and ceftazidime were of equivalent clinical efficacy and safety in treatment of moderate and severe infection.更多还原