【摘要】 相思子毒素是从豆科植物 (AbrusPrecatoriusL .)种子中分离的一种细胞毒性蛋白。它由A ,B两条链组成 ,由一个二硫键相连 ,B链具有半乳糖凝集活性 ,可与细胞膜上受体结合 ,帮助A链进入细胞内 ,A链进入细胞催化 6 0S大亚基的 2 8SrRNA的第 4 32 4位脱去腺嘌呤而使 6 0S核糖体亚基失活 ,从而使细胞蛋白合成被抑制。本文综述了有关相思子毒素的分子结构特点、毒性机制和在临床中的应用前景更多还原

【Abstract】 Abrin is one of the potent toxins isolated from the beans of plant Abrus precatorius L.The toxic protein consists of two disulfide bonded subunits,the A and B chain.The B chain is a galactose specific lectin that facilitates the binding of abrin to the cell membrane and the endocytosis of A chain.After entering the cells,the A chain catalytically inactivates 60S ribosomal subunits by removing adenine position 4324 of 28S r RNA,and thereby inhibits protein biosynthesis.The structural characteristics,toxicological mechanism and clinical application prospect of abrin were reviewed in this paper.更多还原