【摘要】 目的 :研究大黄提取片对单纯性肥胖SD大鼠高胰岛素血症的作用。方法 :口服给药 ,剂量 :2ml 0 2 5g 10 0gB .W . 日 ,高胰岛素血症 (空腹胰岛素水平 >2 5 μu ml)治疗组肥胖大鼠 8只 ,高胰岛素血症对照组肥胖大鼠 8只。血清胰岛素及C肽测定用放免法 ,血清TNFα 测定用ELISA法。结果 :用药一个月后实验治疗组肥胖大鼠减肥同时高胰岛素血症者血清胰岛素及C肽明显降低。TNFα 明显降低 ,血清胰岛素与血清TNFα 间呈显著正相关。结论 :大黄提取片对单纯性肥胖大鼠减肥的同时高胰岛素血症改善 ,此作用与血清TNFα 浓度降低有关更多还原

【Abstract】 Aim:To study effect of the tablet extracted from rhubarb on hyperinsulinmia in simple obese rats.Methods:The simple obese rats with hyperinsulinmia were randomly divided into two groups:experimental group was composed of eight rats,administrated with tablet extracted from rhubarb,0.25g/100gb.w/day,control group:eight rats,administrated with N.S.The serum insulin and peptide C were detected by radioimmunoassay,the serum TNF\|α by ELISA.Results:After administration of tablet extracted from rhubarb for one month,the body weight in experimental rats was obviously reduced,at the same time,the level of insulin,peptide C and TNF\|α remarkably lowered.There is a positive relationship between the serum insulin and TNF\|αlevel.Conclusion:The tablet extracted from rhubarb demonstrated significant effects on reducing body weight and lowering the serum insulin level in hyperinsulinmia in simple obese rats,which may be contributed to the decrease of TNF α level更多还原