【摘要】 目的　观察大剂量、长时间输注 6 %贺斯对消化道肿瘤患者凝血功能的影响。方法　选择 30例术前ASAI II级消化道肿瘤患者 ,入室后抽取静脉血作对照 (T0 ) ,当术中失血量约占总血容量 2 0 %～ 30% ,采用 6 %贺斯补容。术中失血量占总血容量 30 %以上时采用不同比例浓缩红细胞与 6 %贺斯快速扩充血容量。分别在输入不同剂量的 6 %贺斯时抽取静脉血监测APTT、PT、TT、PLT、PCT、MPV及PDW等。结果　当输入 6 %贺斯 2 0 0 0ml时APTT、PT、TT延长 (P <0 .0 5 )但均在正常生理范围内。PLT、PCT、MPV等下降 ,但也均在正常生理范围内。HCT下降 2 3.2 6 % (P <0 .0 1) ,但HCT >0 .2 5。麻醉过程中血流动力学平稳 ,尿量满意。结论　对消化道肿瘤患者在有完备的监测、控制手段下大剂量、长时间输注贺斯对患者的凝血功能影响轻微。更多还原

【Abstract】 Objective To observe the effect of infusion great dosage HAES\|Steril for a long time on the blood coageulation function in the alimentary tract tumor patients.Methods Selected thirty alimentary tract tumor patients of ASA I\|II before operation , collected their venous blood to make contrast after entered the operating\|room .During the operation , when the blood loss volume reached 20%～30% of the total blood volume , adopted 6% HAES\|Steril to expand the blood volume , when the blood loss beyonded 30% , chose aniso\|ratio concitration erythrocyte and 6% HAES\|Steril to expand the blood volume swifly. To draw blood to monitor APTT?PT?TT?PLT?PCT?MPV and PDW ,et al . each time when infusion 6% HAES\|Steril 1000ml (T1)?1500ml (T2)?2000ml (T3) . Results when infusion 6% HAES\|Steril 2000ml APTT?PT?TT were all prolonged ( P <0.05) , PLT?PCT?MPV were descented , but they were all in the normal physio\| Coverage.HCT descented 23.26% ( P <0.01) , but it surpassed 0.25 . During anesthesia , the hemodynamics was stable , Urine volume was satisfactied.Conclusion while perfect monitoring and controling methods are used . there is a slight effect of infusion great dosage HAES\|Steril for a long time on the blood coagulatlon of alimentary tract in the tumor patients.更多还原