【摘要】 目的 :评价一个新的胆碱酯酶抑制剂 TAK- 14 7对大鼠空间学习记忆的作用。方法 :用水迷宫来评价大鼠空间学习记忆 ,用开场实验方法来分析大鼠的自发活动能力。结果 :在学习过程中 ,腹腔内注射东莨菪碱 (0 .4mg/ kg)明显造成了大鼠空间学习记忆障碍 ,延长了其上台潜伏期。腹腔内注射 TAK- 14 7能剂量依赖性地改善东莨菪碱造成的学习障碍 ,在 0 .3和 1.0 mg/ kg的剂量具有显著性意义。在记忆再现过程中 ,由东莨菪碱 (1.5 mg/kg)造成的上台潜伏期延长也分别被 TAK- 14 7(0 .3mg/ kg和 1.0 mg/ kg)和他克林 (3.0 mg/ kg和 5 .0 mg/ kg)明显逆转 ,且 TAK- 14 7的作用强于他克林。在开场实验中 ,TAK- 14 7组与东莨菪碱组或生理盐水组比较 ,自发活动能力没有明显改变。结论 :TAK- 14 7作为一个新的胆碱酯酶抑制剂 ,能明显改善东莨菪碱造成的大鼠空间学习记忆障碍。更多还原

【Abstract】 Objective: To evaluate the effects of TAK 147, a novel acetylcholinesterase inhibitor on rat spatial memory deficit using the Morris water maze. Methods: Morris water maze was used to measure spatial memory in rats, and open field test was used to analysis locomotor activity. Results: Scopolamine (0.4 mg/kg, IP) significantly increased the latency period in memory acquisition. Intraperitoneal TAK 147 injection ameliorated scopolamine induced deficit in a dose related manner. A significant effect was obtained at doses of 0.3 and 1.0 mg/kg. Both TAK 147 (0.3 and 1.0 mg/kg) and tacrine (3 and 5 mg/kg) significantly reversed scopolamine (1.5 mg/kg) increased latency in memory retrieval. However, TAK 147 had a more potent effect than tacrine. In the locomotor test, TAK 147 created no appreciable change, compared with scopolamine or saline. Conclusion: A novel acetylcholinesterase inhibitor, TAK 147 ameliorates the scopolamine induced impaired spatial memory in rats.更多还原