【摘要】 目的　探讨汉防己甲素对白内障摘除术后晶状体后囊膜混浊形成的影响及其作用机制。方法　对 4 8只实验兔行单眼囊外晶状体摘除及人工晶状体植入术。术前随机分为A组对照、B组术后结膜下注射地塞米松、C组术后结膜下注射汉防己甲素和D组术中植入汉防己甲素镀膜人工晶状体。术后不同时间检测各组术眼的房水细胞数、蛋白质和丙二醛含量 ,记录晶状体后囊膜混浊程度和湿重。结果　除术后 14d房水丙二醛含量外 ,囊外晶状体摘除术后不同时间 4个组的房水细胞数、蛋白质和丙二醛含量 ,以及晶状体后囊膜混浊的程度和湿重差异均有显著意义 (P <0 0 5 )。其中B和C组术后不同时间房水细胞数、蛋白质和丙二醛含量均低于A组 ,差异有显著意义(P <0 0 5 ) ;B、C和D组术后不同时间晶状体后囊膜混浊的程度和湿重均低于A组 ,差异有显著意义(P <0 0 5 )。　结论　汉防己甲素可有效抑制兔眼晶状体摘除术后晶状体后囊膜混浊的形成 ;其最佳用药剂量和途径尚需深入探讨更多还原

【Abstract】 Objective To study the effect of tetrandrine (Tet) on the formation of posterior capsular opacification (PCO) after cataract extraction Methods Intraocular lens implantation was performed on 48 healthy rabbit eyes, and they were randomly divided into 4 groups: control (A), dexamethasone (B), Tet (C) and Tet with coated IOL (D) Dexamethasone and Tet were postoperatively injected into the subconjunctival space The number of cells, the contents of protein and malondialdehyde (MDA) in the aqueous were determined at different days postoperatively The PCO was scored and opaque posterior capsules were weighted Results The number of cells, the amount of protein in aqueous, the scales and the wet weight of PCO in the treated eyes were less than that of the control eyes ( P <0 05) In B and C group, except the 14th day content, the postoperative MDA was lower than that in the control group ( P <0 05) Conclusion Tet can inhibit the formation of PCO, and has no obvious toxicity to the corneal endothelium更多还原