【摘要】 目的　为了探讨宫颈癌和宫颈上皮内瘤变 (CIN )组织中热休克蛋白 70 (HSP70 )的表达与人乳头瘤病毒(HPV )感染的关系。方法　用免疫组化和原位PCR技术对 66例宫颈癌和 2 5例CIN组织进行检测。结果　宫颈癌、CIN和正常宫颈组织中HSP70表达率为 80 .3 %、72 .0 %和 2 0 .0 % (P <0 .0 1,P <0 .0 5 )。 5 2例HPVDNA阳性的宫颈癌组织中有 45例 (86.5 % )HSP70表达阳性 ,明显高于HPVDNA阴性组织 (5 7.1% ,P <0 .0 5 )。结论　HSP70与宫颈癌、CIN的发生发展有密切关系 ,HPV可以诱导宫颈癌和CIN细胞中HSP70的高表达。更多还原

【Abstract】 ObjectiveTo investigate the expression of heat shock protein 70(HSP70) and infection of human papillomavirus (HPV) in cervical carcinoma and cervical intraepithelial neoplasia(CIN).MethodsImmunohistochemial and in situ PCR were used to detect the expression of HSP70 and HPV in 66 cervical carcinomas and 25 CIN.ResultsThe positive staining rates of HSP70 in cervical carcinoma,CIN and normal cervical tissues were 80.3%,72.0% and 20.0% (P<0.01,P<0.05).Forty-five (86.5%) positive expression of HSP70 was found in 52 HPVDNA positive,being significantly higher than the HPV negative cervical carcinoma tissues (57.1%,P<0.05).ConclusionThere is a close relationship between the HSP70 and the development of cervical carcinoma and CIN.The overexpression of HSP70 can be induced by HPV in cervical carcinoma and CIN cell.更多还原