【摘要】 目的:观察胰岛素吸入粉雾剂肺部给药后的降血糖效果.方法:胰岛素与合适辅料制成的干粉经大鼠肺气管切口吹入肺中,测定随后7小时的血糖浓度,以血糖曲线上面积(AAC)为指标对其药效进行评价.结果:吸入胰岛素剂量为20,10,5和2.5U/kg时,最低血糖浓度可分别降至给药前的6.5％,16.6％,24.6％和57.0％;剂量为5 U/kg吸入给药的AAC值和5U/kg皮下注射给药的AAC值相近;AAC值与对数剂量间存在线性关系.结论:胰岛素肺部给药的降血糖效果明显且作用迅速.更多还原

【Abstract】 AIM: To observe the hypoglycemic efficacy of pulmonary delivery of insulin in dry powder aerosol form. METHODS: Insulin dry powder, made of insulin and other proper materials, was insufflated in rat lung from an incision in the throat. Meanwhile, insulin injection was administered to other rats. Glucose concentration in blood was determined in the following 7 h. The areas above the curve (AAC) of glucose concentration in blood were used to evaluate the efficacy. RESULTS: The percent minimum blood glucose levels, compared with the glucose levels before the administration , for pulmonary delivered insulin at the doses of 20, 10, 5, and 2.5 U/kg were 6.5 % , 16.6 % , 24.6 % , and 57.0 % , respectively. The AAC of insulin 5 U/kg by pulmonary delivery was very close to that of subcutaneous administration at the same dose. There was a linear relationship between AAC and the logarithmic dose of pulmonary delivered insulin. CONCLUSION: The pulmonary delivery of insulin acts effectively and rapidly.更多还原