【摘要】 目的在原发性高血压病人中探讨室壁中层缩短分数 (mFS)的降低与早期心肌收缩功能减退与靶器官器质性损伤的相互关系。方法　比较mFS降低组与正常组病人静息位与最大药物负荷时左室射血分数 (EF)等的差异、以及心室质量、尿蛋白的组间差异。结果　静息位两组病人心功能无差异 ;mFS减低组的药物负荷核素心血池显象EF多有异常 ,伴心室质量增加及尿蛋白定性明显增加。结论　高血压病人mFS减退提示早期心室功能减退伴心脏、肾脏器质性损害更多还原

【Abstract】 Objective To evaluate the relationship of subnormal midwall fractional shortening (mFS) with early damage of left ventricular(LV) systolic function and damage in target organs in patients with essential hypertension. Methods Radionuclide cineangiographic LV ejectoin fraction(EF) at rest and maximum dobatamine stress test, LV mass, urine protein were compared between groups with subnormal mFS and normal mFS. Results No difference of resting cardiac function between the two groups was found; subnormal mFS is associated with abnormal EF change of dobutamine stressed radionuclide ventriculography, increased LV mass, and increased urine protein. Conclusion Early damage of LV systolic function usually manifested as abnormal mFS, which often accompanied by impairment of LV and kidney.更多还原