【摘要】 目的 :研究水蛭注射液对小鼠体内血栓形成和血浆纤溶酶原激活物 (t PA)及抑制物 (PAI)的影响。方法 :给不同组小鼠分别注射不同剂量水蛭注射液。用角叉菜胶诱发小鼠体内血栓形成。发色底物法测定血浆t PA及PAI活性。结果 :水蛭组与血栓对照组相比 ,尾部血栓形成长度百分数明显缩短 ,PAI明显降低 (P <0 .0 5 )。结论 :水蛭注射液具有抗栓作用 ,其作用机理可能主要与减少血浆PAI的释放有关更多还原

【Abstract】 Objective: To investigate the effect of leech injection on thrombosis and plasma tissue plasminogen activator (t PA) and its inhibitor (PAI) in the thrombosis model of mice. Methods: The different dose leech injection of different doses were given to mice in different groups for 7 days respectively. Thrombosis was induced in mice by carrageenan. The plasma t PA and PAI activity were detected by chromogennic substracte analysis.Results: The average thrombosis length of tail in the groups of leech injection were significantly shorter than the length in the groups of thrombosis control. Compared with the group of thrombosis control, the plasma PAI activity in the leech injection groups was lower. Conclusions: The leech injection can reduce thrombosis in mice. The mechanism might be associated with reducing the release of PAI.更多还原