【摘要】 目的探讨绝经后骨质疏松有效的预防措施。方法采用激素替代治疗(HRT)中的连续联合治疗方案,每日服用倍美安1片,连续半年,测定服药前后的血碱性磷酸酶(ALP)、骨钙素(BGP)、空腹尿钙/肌酐(Ca/Cr)、骨矿含量(BMC)、雌酮(E1)、雌二醇(E2)、睾酮(T)。结果与服药前相比较,ALP、BGP、Ca/Cr有显著性下降,以Ca/Cr下降最为显著,BMC维持不变,对照组的BMC下降4.9%。结论HRT对骨形成和骨吸收均有抑制作用,但以抑制骨吸收为主,从而防止骨丢失,保持骨量,预防骨质疏松。更多还原

【Abstract】 Objective To explore efficient method to prevent postmenopausal osteoporosis.Method The women took hormone replace therapy (HRT) for six months. The difference of blood alkaline phosphatase (ALP), bone gla protein(BGP),urine gla/creatine(Ca/Cr), bone mineral content (BMC), estrone(E1), estradiol(E2) and testosterone (T) before and after taking the drug were analysed.Result After taking the drug for six months, ALP,BGP,Ca/Cr descreased differencitly.BMC maintained.The BMC of the contrastant group descreased 4.9%.Conclusion The HRT restrained bone absorption and bone forming.The bone absorption was resteained outstandly.The scheme of continuous uniting could prevent postmenopausal osteoporosis (PMO).更多还原