【摘要】 目的 :观察重组人骨形成蛋白 2 (rhBMP2 )作间接盖髓剂时对牙本质形成的影响。方法 :采用间接盖髓术 ,在规定时间内给狗口服四环素 ,在 135d拔除试验牙 ,制作牙磨片 ,在萤光显微镜下观察修复性牙本质形成情况。结果 :所形成修复性牙本质的量 ,rhBMP2明显多于对照组。结论 :rhBMP2用于间接盖髓 ,同样有高效的诱导作用。它将是一种很有价值、应用性很强的生物活性间接盖髓剂更多还原

【Abstract】 Objective: To investigate the reparative dentine formation induced by the recombinant human bone morphorgenetic protein2(rhBMP2) used as a indirect pulp capping agent in dog teeth. Methods: Type V cavities were prepared in 48 teeth of 2 dogs. rhBMP2 with zinc oxide(A) was lined on the bottom of 24 cavities, saline with zinc oxide(B) in 12 and zinc oxide eugentol cement(C) in 12. 0.5 g of tetracycline was orally administered to the dogs twice a day on day 24, 54, 83 and 111. On day 135, the teeth were extracted and processed for the quantitative observation of reparative dentin under a fluorescent microscope .Results: On day 135, the reparative dentine (expressed as "μm" of diameter of area) in group A, B and C was 825.04± 125.46, 315.33± 80.43 and 415.25± 90.75 respectively(P<0.0005). Conclusion: rhBMP2 can be used as bioactive pulp capping agent in dental treatment.更多还原