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苯乙烯对接触男工的遗传毒性

Genotoxicity of exposure to styrene in male workers

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【作者】 陈锦沈波程怀民程生英李跃平林炜李胜阳

【Author】 CHEN Jin 1,SHEN Bo 2,CHENG Huai min 2,CHENG Sheng ying 2,LI Yue ping 1,LIN Wei 1,LI Sheng yang 1 (1.Department of Preventive Medicine,Fujian Medical University,Fuzhou 350004,China;2.Epidemic Prevention Station of Jinan Region in Fuzhou,Fuzho

【机构】 福建医科大学预防医学系福州市晋安区防疫站福建医科大学预防医学系 福建福州350004福建福州350000福建福州350004福建

【摘要】 目的 探讨苯乙烯对作业工人的遗传损害。方法 选择某厂从事苯乙烯作业男工 3 0名 ,平均工龄 4 5年 ,以微核检测进行细胞遗传毒性效应研究。结果 工人在苯乙烯平均浓度为 99mg/m3的作业环境中工作 ,微核发生率明显增高 ,且随着工龄的延长 ,微核发生率有增高的趋势。结论 苯乙烯对接触男工有一定的遗传毒作用 ,应引起重视 ,并加强对苯乙烯作业环境的监测和作业人群的防护。

【Abstract】 Objective To explore the genetic damage to male workers exposed to styrene.Methods Thirty male workers exposed to styrene and 44 unexposed controls,with an average length of employment of 4 5 years,were selected from a factory,and 0 3 ml of blood were collected from each of them and cultured for 72 hours for examination of lymphocytic micronucleus as a genotoxic measure.Results Micronucleus rate in those working in an environment with 99 mg/m 3 of styrene increased significantly in comparison with unexposed controls,and increased with length of employment.Conclusions Styrene could cause genotoxicity in exposed workers,and environmental monitoring and protecting for the exposed workers should be strengthened.

【关键词】 苯乙烯遗传毒性淋巴细胞微核
【Key words】 StyreneGenotoxicityLymphocytic micronucleus
【基金】 福建省卫生厅青年基金资助 (编号 :99- 1 - 2 0 )
  • 【文献出处】 中国工业医学杂志 ,Chinese Journal of Industrial Medicine , 编辑部邮箱 ,2002年01期
  • 【分类号】R99
  • 【被引频次】9
  • 【下载频次】95
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