【摘要】 通过氯化锰给小鼠腹腔注射染毒 ,研究锰对雄性生殖细胞的遗传毒性。显性致死试验 5 0mg/kg组见平均死胎数和突变指数 ,与阴性对照组比较差异有显著性 (P <0 0 5 )。睾丸染色体畸变分析亦仅 5 0mg/kg剂量组见常染色体和性染色体早熟分离 ,与阴性对照组差异有统计学意义 (P <0 0 5 )。本实验结果显示 ,锰对雄性生殖细胞有诱变性更多还原

【Abstract】 To study the genetic toxicity of manganese on reproductive cells of male mice via injecting manganese chloride i p in mice.The dominant lethal test of manganese chloride at 50 mg/kg level showed that the average stillbirth number and the mutagenic index were significantly higher than those of negative control(P<0 05),and the incidence of premature separation in autosomes and sex chromosomes was also more significant than negative control group at the dose of 50 mg/kg(P<0 05)by analysing the aberration of testis chromosomes.The study suggests that manganese has the mutagenicity on reproductive cells of male mice.更多还原