【摘要】 目的 :研究和比较脑腱性黄色瘤病 (CTX)病人和健康正常者的血清胆固醇异构体的含量差异 ,建立血清胆固醇异构体的定量测定方法。方法 :用HPLC法测定血清胆固醇含量。结果 :CTX病人的血清二氢胆固醇含量是健康正常者的 2 0倍。结论 :该法简便快速 ,灵敏度高 ,能定量测定极微量的二氢胆固醇 ,为诊断脑腱性黄色瘤病提供依据更多还原

【Abstract】 Objective:To study and compare the contents difference of cholesterol isomers in blood serum between the patients with cerebrotendinous xanthomatosis and healthy normal subjects,and establishing the method of quantitative analysis of serum cholesterol isomers.Methods:The quantitative analysis of serum cholesterol isomer was evaluated by high performance liquid chromatography(HPLC).Results:The contents of serum cholestanol in the patients with cerebrotendinous xanthomatosis was 20 times of that of healthy normal subjects.Conclusion:This method was found to be simple,quick and sensitive.And can measure the exceeding trace cholestanol,to provide the referenced foundation for the diagnosis of cerebrotendinous xanthomatosis.更多还原