【摘要】 目的　探讨联合应用钠氢离子交换抑制剂(NHE I)Cariporide与肾上腺素在心肺复苏中的效果。方法　 16只历经 12min室颤的大鼠配对分为 2组 (Cariporide组及对照组 ) ,分别在心肺复苏 (CPR)前注入Cariporide或等容量的生理盐水。CPR第 2min结束前始注入肾上腺素 ,使CPP维持在 2 5mmHg以上。对照组与匹配的Cariporide组有对应的除颤时间。对心肺复苏 8min后未能自动复率大鼠进行电除颤。结果　与对照组相比 ,以同样的高度进行胸前心脏按压 ,cariporide组须较小剂量的肾上腺素便可获得较高、持续时间较长的冠脉灌注压 (P <0 0 5 ) ,较高的复苏率 (P <0 0 5 )、较少的复苏后异位室性心律失常 (P <0 0 0 1)、较好的血流动力学效果及较长的生存时间 (P <0 0 5 )。结论　联合应用Cariporide及肾上腺素可提高心室纤颤的复苏效果。更多还原

【Abstract】 Objectives To test the resuscitative effects from prolonged ventricular fibrillation by epinephrine combined with sodium hydrogen exchanger isoform 1 inhibitor Cariporide. Methods 16 rats were received a 3 mg/kg bolus of Cariporide or the same volume of 0 9% NaCl solution (control) 15 seconds before completion 12 minutes untreated VF. Chest compression (CC) was started for a total of 8 minutes. Adjusted the depth of compressor so that the aortic diastolic pressure to 25～28 mmHg during the 2 nd minute of CC. Fix the depth of the piston and this depth was used throughout the remaining 6 minutes of CC. 10 seconds before starting the 3 rd minute of chest compression,injected epinephrine (30 μg/kg). Recorded the time at which restoration of spontaneous circulation (ROSC) occurred in Cariporide treated rats. Electrical defibrillation was timed in control group to match the time of spontaneous defibrillation in Cariporide treated rats. To the rats,which can’t be defibrillated spontaneously,received chest compression and rescues electrical shocks. Results Compared with control group, with the same CC depth,Cariporide treated rats received the higher and longer lasting coronary perfusion pressure ( P <0 05), higher resuscitative rate ( P <0 05),less post resuscitative ventricular ectopic activities ( P <0 001),better hemodynamic effects and longer survival time ( P <0 05). Conclusion Epinephrine combined with sodium hydrogen exchanger isoform 1 inhibitor Cariporide may represent a novel and remarkably effective intervention for resuscitation from prolonged VF.更多还原