【摘要】 本文以甲基丙烯酸缩水甘油酯为单体,三聚异氰尿酸三烯丙酯和二乙烯基苯为交联剂,甲苯和正庚烷为有机致孔剂,用原位聚合的方法合成亲水性高分子载体。胺化反应后,得到含二乙胺基羟丙基的阴离子交换剂(树脂A)。研究了不同的合成配比对该树脂吸附牛血清白蛋白行为的影响,从而获得一个较佳的合成配方。在此基础上,采用固体颗粒与有机溶剂联合致孔模式,以硫酸钠颗粒为固体致孔剂,制备新型双孔离子交换剂(树脂B)。比较了两种树脂的孔结构及其对牛血清白蛋白的吸附行为。结果表明,树脂A和树脂B均具有较高的吸附容量和较好的机械性能。由于树脂B内含有流动相可以对流通过的大孔结构,因此同时还具有相对较好的吸附动力学性能。更多还原

【Abstract】 A porous matrix, a ternary co-polymer of glycidyl methacrylate, triallyl isocyanurate and divinylbenzene, was fabricated by a simple in situ co-polymerization with toluene and n-heptane as porogenic agents. After functionalized with diethylamine, the resin (denoted as Resin A) was used as an anion-exchanger. Efforts were made to enhance protein ion-exchange capacity of the resin by investigating the co-polymer composition. Different synthesis recipes were attempted and the resultant resins were characterized by measuring the adsorption ability using bovine serum albumin (BSA) as a model protein. Then, a novel biporous resin (denoted as Resin B) was prepared with granules of sodium sulfate and toluene and n-heptane as porogenic agents based on the concept of a novel porogenic mode, cooperation of solid granule and solvent. The pore structure and adsorption behavior to BSA of Resin B were characterized and compared with those of Resin A. The results indicated that Resins A and B both had high adsorption capacities and good mechanical strength. Due to the presence of macropores in Resin B, protein molecules could transport into the interior part of the particle by convective flow. Therefore, Resin B had a higher effective pore diffusivity of protein than Resin A.更多还原