【摘要】 目的 :研究雌激素替代治疗对骨质疏松时种植体骨愈合的影响。方法 :选用32周龄雌性SD大鼠36只 ,并随机分为假手术组、卵巢切除组及雌激素组。卵巢切除12周后于大鼠胫骨近中干骺端植入纯钛螺纹状种植体 ,雌激素组同时肌注苯甲酸雌二醇。种植术后4周及12周分两批处死大鼠 ,摘取胫骨 ;标本分别进行扫描电镜观察和骨计量学测量。结果 :在种植后4周及12周时 ,雌激素组除12周时皮质骨结合率与卵巢切除组无显著差异外 ,其它各项骨计量学参数均显著高于卵巢切除组 (P<0.05或P<0.01) ;而与假手术组比较 ,除骨矿化速度及4周时单位骨量外 ,其他各项指标均无显著差异 (P>0.05)。电镜观察种植体—骨界面愈合雌激素组和假手术组均优于卵巢切除组。结论 :雌激素替代治疗可促进实验性骨质疏松大鼠种植体骨愈合 ;该方法有助于增加临床绝经性骨质疏松患者牙种植体骨整合率更多还原

【Abstract】 Objective:To investigate the effect of estrogen replacement therapy on bone healing around titanium implants in ovariectomized rats. Method: Thirty six 32-week-old female SD rats were randomly divided into three groups, an ovariectomized group, a sham-operated group and an estrogen-replacement-therapy group. Pure screw titanium implants were placed in the proximal metaphyses of the tibiae 12 weeks after ovariectomy surgery, and the rats in estrogen group were prescribed benzyl estradiol . The tibiae were examined hisotologically by undecalcified sections with bone histomorphometric method and by scanning electron microscope at intervals of 4 and 12 weeks after implant surgery. Results: At 4 and 12 weeks after implant surgery, all the bone histomorphometric paremeters except cortical implant-bone contact rate at 12 weeks, were significantly increased in estrogen group compared with ovariectomized group. While compared with sham-operated group, all above parameters except bone mineralization rate and density of trabecular bone around implants at 4 weeks , which were significantly different, did not show any apparent changes in the estrogen group. Conclusion:Estrogen replacement therapy promotes bone healing around titanium implants in ovariectomized rats, and it may also play a similar role in osseointegration of dental implants in postmenopausal ostoeporotic patients.更多还原