【摘要】 目的 :探讨一种新的肾性骨病大鼠模型制作方法。方法 :采用 3/ 4肾切除加高磷饮食 6月动态观察肾功能、骨代谢指标及骨病理改变。结果 :模型组血尿素氮、肌酐、磷、甲状旁腺素进行性升高 ,钙进行性降低 ,骨代谢指标血清碱性磷酸酶、骨钙素、尿脱氧吡啶酚显著升高 ,骨病理改变与人肾性骨病相似。结论 :3/ 4肾切除加高磷饮食是一种较为理想的肾性骨病大鼠模型的制备方法更多还原

【Abstract】 Objective:To explore a new kind of method of making animal model of renal osteod strophy. Methods:Rats were 3/4 nephrectomized, Six months dynamic observation was done in the change of renal function, marks of bone metaboly and bone pathology. Results:Serum concentration of BUN、Cr、P、Ca、PTH、AKP、BGP and urinary DPD of model groups raised obviously, serum concentration of Ca was reduced, pathologic lesion of bone tissue was like with human. Conclusion: 3/4 nephrectomy combined with high dietary phosphorus is a ideal method of making rat model of renal osteodstrophy.更多还原