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唾液碘的测定及其与尿碘的相关性

Iodine determination in salivary samples and the relationship between iodine concentration in saliva and urine

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【作者】 张京玲宋佳音高建华赵文德焦建杰娄建石陈祖培

【Author】 ZHANG Jing -ling,SONG Jia -yin,GAO J ian -hua,et al(Department of Pharmacology,Tianji n Medical University,Tianjin 300070)

【机构】 天津医科大学基础医学院药理教研室天津医科大学内分泌研究所天津医科大学内分泌研究所 天津300070天津300070天津300070

【摘要】 目的建立唾液碘的测定方法,探讨唾液碘与尿碘的相关性。方法用酸消化砷铈催化分光光度法测定33例青年男女正常健康志愿者不同时间的唾液及尿液中的碘含量。结果健康志愿者的唾液碘及尿碘均呈偏态分布,其中位数值分别为102.7μg/L和215.6μg/L。男女性别之间无显著性差异,且随取样时间不同,唾液碘及尿碘变化曲线也不相同。由所测数值进行统计学分析推算出18~22岁成人组唾液碘的正常值范围为70~150μg/L,尿碘的正常值范围为130~280μg/L。结论唾液碘与尿碘间存在着较好的相关性。

【Abstract】 Objective To develop a method of monitoring con centrations of iodine in salivary sa mples and study the rela-tionship between iodine in saliva an d urine.Methods The salivary and urine samples were g ot from 33healthy volunteers at 8,10,14,16,18,20o ’clock,respectively.We determined the iodine in these samples by using t he methods of acid digestion and ar-senic -cerium catalytic spectrophotometry.Results The median values of urinary and sali vary iodine were 215.6μg /L and102.7μg /L,respectively,their distribut ion curves are skew.There was no sign ificant difference between male and female(P>0.05).However,the curve of urine iodine within 12hours looked like a sine curv e and peak value is higher than that of salivary curve.But the curve of salivary iodi ne looked like a line,peak value is not high.According to statistic analy sis,we have got the nor-mal iodine range of saliva and urine i n 18~22years old healthy adults.They are 75~150μg /L and 130~280μg /L,respective-ly.Conclusion The methods of determination of salivary iodine is simple,reliable,acc urate and stable.There is a good rela tion-ship between salivary iodine and urine iodine.The normal iodine range of saliva and urine in 18~22years old healthy adults are75~150μg /L and 130~280μg /L,respectively.

【基金】 天津医科大学自然科学基金资助项目(049200004)
  • 【文献出处】 中国地方病防治杂志 ,Chinese Journal of Control of Endemic Disease , 编辑部邮箱 ,2002年05期
  • 【分类号】R599
  • 【被引频次】3
  • 【下载频次】126
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