【摘要】 目的 :探讨早期诊断肾脏损伤的方法 ,联合尿NAG及尿mALB两项指标对于肾病的早期诊断具有一定的价值。方法 :采用速率法测定尿NAG、血尿素 (BU) ,Jaffe速率法测尿肌酐 ,免疫速率散射比浊法测尿mALB。结果 :正常对照组尿NAG为 (9.37± 4 .2 1)IU/ gCr ,尿mALB为 (12±10 ) μg/ml,血尿素为 (4.71± 1.5 0 )mmol/L ,疾病组尿NAG及mALB较正常对照组显著增高 (P <0 .0 0 1) ;糖尿病组血尿素较正常对照组显著增高 (P <0 .0 0 1) ,高血压组血尿素较正常对照组增高(P <0 .0 5 ) ,红斑狼疮与尿路感染组血尿素较正常对照组无显著性差异。尿NAG在糖尿病、高血压、系统性红斑狼疮及尿路感染中阳性率分别达 5 6 .2 5 %、5 2 .17%、4 0 %和 4 0 % ,分别较血BU的阳性检出率高出 34.37%、34.78%、2 0 %和 2 6 .6 7% ;而尿mALB在糖尿病、高血压、系统性红斑狼疮及尿路感染中阳性率分别为 5 0 %、4 7.82 %、5 0 %和 4 6 .6 7% ,分别较血BU的阳性检出率高出2 8.12 %、30 .4 3%、30 %和 33.34%。结论 :尿NAG及mALB是诊断肾脏早期损伤灵敏、可靠的实验室指标。更多还原

【Abstract】 Objective: To provide diagnostic basis for early renal disease,Measuring both urinary NAG and urinary microalbumin can get a higher positive rate.Methods: Urinary N-acetyl-β-D-glucosaminidade (NAG)and blood urea were determined with rate,Urinary creatinine was determined with Jaffe’s rate,mALB levels was measured with rate nepherometry. Results: The levels of urinary NAG and blood urea in the controls were (9.37±4.21)IU/gCr and (4.71±1.50)mmol/L,urinary mALB was (12±10)μg/ml. The level of urinary NAG and urinary microalbumin in each group (diabetes,hypertension,lupus erythematosus and uretha infection)were obviously higher than that in the control( P <0.001); Blood urea in diabetes and hypertension groups were higher than that in the control ( P <0.001, P <0.05),In lupus erythematosus and urethra infection weren’t higher.Positive rates of urinary NAG in diabetes,hypertension,lupus erythematosus and urethra infection groups were 56.25%,52.17% ,40% and 40%,respectively.They were higher than the positive rate of blood urea by 34.37%,34.78%,20.% and 26.67%,respectively. Positive rates of urinary microalbumin in diabetes,hypertension,lupus erythematosus and urethra infection groups were 50%,47.82% ,50% and 46.67%,respectively.They were higher than the positive rate of blood urea by 28.12%,30.43%,30.% and 33.34%,respectively. Conclusion: The urinary NAG and urinary mALB is sensitive and reliable for diagnose of early renal disease.更多还原