【摘要】 ①目的　探讨短期应用单克隆抗体CD3 (OKT3 )预防肾移植术后早期严重排斥反应的效果和安全性。②方法　对照组 35例肾移植病人术后常规应用甲基泼尼松龙、环磷酰胺、泼尼松、骁悉和环孢霉素A ;实验组33例在上述用药基础上 ,术后前 5d连续应用OKT3 5mg静脉注射。③结果　实验组除 1例肾小管坏死的病人因发生急性排斥反应、自发性移植肾破裂而切除肾脏 ,无其他严重并发症。对照组 2例发生加速排斥反应 ,应用OKT3 后 1例加速排斥反应逆转 ,1例死亡 ;4例发生急性排斥反应 ,应用OKT3 后全部逆转。两组排斥反应发生率比较差异有显著性 (χ2 =4 .72 5 ,P <0 .0 5 )。④结论　肾移植术后短期应用OKT3 能有效地预防早期严重排斥反应 ,而未引起严重并发症更多还原

【Abstract】 Objective\ To investigate the effect and reliability of using OKT 3 for a short period to prevent early post operative severe rejections in kidney recipients. \ Methods\ Methylprednisolone, Cyclophosphamide, Prednisolone, Mycophenolate Mofetil, and Cyclosporine A were routinely used in the Control Group (35 recipients). OKT 3 (5mg/d) was administered intravenously in the Experimental Group (33 recipients) for the first 5 days after operation , in addition to above drugs used in the Control Group. \ Results\ In the Experimental Group, an acute rejection occurred in 1 patient with acute tubule necrosis and the transplanted kidney was eventually removed because of spontaneous rupture. There were no other severe complications found in this group. In the Control Group, 2 accelerated rejections and 4 acute rejections occurred in 6 patients, one of them with accelerated rejection died and the others rehabilitated after administration of OKT 3. The difference was significant between the two groups ( χ 2 =4.725,P <0.05).\ Conclusion\ An application of OKT 3 for a short period after operation is effective and safe in the prevention of early severe rejections in kidney recipients.更多还原