【摘要】 目的　研究亳州市城区新生儿接种乙型肝炎 (以下简称乙肝 )疫苗免疫效果及影响因素。方法　血清学检测和流行病学调查相结合。结果　 1994～ 2 0 0 0年新生儿乙肝疫苗 7年平均接种率达 91.80 % ;新生儿乙肝疫苗免疫成功率达 96 .0 0 %。 1～ 7岁组儿童抗 -HBs阳性率达到 94 .0 0 % ,较实行计划免疫前 8.5 7%明显升高。接种儿童较未接种的同年龄组儿童HBsAg阳性率下降 70 .5 4 % ,抗 -HBc下降 83.82 % ;实施计划免疫前 ,目标人群乙肝发病率 (12 1.72 / 10万 )较实施后的同年龄组儿童乙肝发病率 (2 0 .2 8/ 10万 )下降了 83.34%。结论　影响新生儿乙肝疫苗接种的重要因素有 :儿童家长对乙肝的认识程度、受教育水平、儿童的出生场所等。更多还原

【Abstract】 An evaluation of efficacy of expanded programme on immunization of hepatitis B vaccine of infants in the urban area of BoZhou city was carried out. The annual average reported coverage was 91.8% in 1994～2000. The effective rate of immunization of hepatitis B vaccine was 96.00% in infants. The anti-HBs positive rate was increased to 94.00% in the 1～7 year age group after the immunization of hepatitis B vaccine. It was significantly higher than that (8.57%) in the same age group before immunization. Positive rate of HBsAg was decreased 70.54% while the anti-HBc positive rate was decreased 83.82% in the same age group after the immunization compared with previous rate. The epidemiological evaluation of the efficacy showed that the incidence of hepatitis B was decreased from 121.72/10 6 to 20.28/10 6 in the targeted population after the administration of immunization. The important factors that affecting HB vaccination were the birth place of the newborns, and parents education level.更多还原