【摘要】 目的:研究川乌及川乌配伍防己对炎症因子和自由基的作用。方法:制备川乌、防己单味及合用水煎液,采用大、小鼠炎症模型,观察 SOD 及 LPO 含量的变化。结果:川乌配伍防己能增强各单味药尤其是川鸟的抗炎作用,降低炎症过程中毛细血管通透性和炎症介质 PGE₂的含量;减少川乌所致升高的血浆及肝组织 LPO 含量。结论:以上抑制炎症因子和清除自由基的结果,可能是川乌与防己配伍能增强单味药尤其是川乌抗炎祛风湿的重要机理之一。更多还原

【Abstract】 To study the single and combined effect of using Aconitum carmichaeli（AC）with Stephana tetrandrae（ST）in treating inflammatory factors and free radicals.Methods:Prepare the single and combined decoction or AC and ST,introducing them into the peritoneum for 7 days,using the mice and rats inflammation model,and erythrocyte superoxide dismutase and serum lipid peroxidase were determined.Results:Combined AC-ST treatment strengthened the anti-inflammatory effect（carrageenin or formaldehyde induced paw edema and xylene induced ear swellin）of AC and ST alone,AC in particular,it lessened capillary permeability and the content of PGE₂,reduced the AC induced plasma and liver tissue LPO in high level.Conclusion:The result of anti-inflammatory factor and free radical scavenging could be the important mechanism of combined AC-ST reinforced the anti-inflammatory and anti-rheumatic effect of single AC or ST,particularly the AC.更多还原