【摘要】 目的:观察丹参、大黄对急性肝损伤时肝脏能量代谢的影响,以明确其保肝抗损伤之机理。方法:丹参、大黄注射液皮下注射防治硫代乙酰胺(TAA)灌胃染毒所致大鼠急性肝损伤,应用酶荧光法测定动脉血中乙酰乙酸、β-羟基丁酸浓度。结果:丹参与大黄组动脉血酮体比、动脉血中总酮体浓度显著高于 TAA组(P<0.05,P<0.01);血清丙氨酸转氨酶活性、总胆红素含量、血浆内毒素水平显著低于 TAA 组(P<0.05)。结论:应用丹参、大黄可提高急性肝损伤时肝脏能量储备水平,这可能与丹参、大黄下调血浆内毒素水平相关。更多还原

【Abstract】 Objective:To observe the effect of salvia or rhubarb on hepatic energy metabolism in acute liver injury to elucidate the mechanism of the two herbs in protection against liver injury.Methods:Salvia or rhubarb injection was administered hypodermically to rats for pre- vention or treatment of acute liver injury intoxicated by thioacetamide(TAA)orally taken.The arterial blood levels of acetoacetate(A- CAC) and β-hydroxybutyrate(β-OHB) were determined using enzymatic fluorimetric method.Results:The arterial blood levels of ketone body ratio and total ketone body of salvia or rhubarb group were significantly higher(P<0.05 and P<0.01)than those of the TAA group;and the serum alanine transaminase activity,total bilirubin content and plasma endotoxin level were lower(all P<0.05)in the rats treated with salvia or rhubarb than those in untreated intoxicated rats.Conclusion:Hepatic energy could be increased by administra- tion of salvia or rhubarb,the mechanism might be related to the plasma endotoxin down-modulating action of the herbs.更多还原