【摘要】 [目的 ]通过前瞻性临床观察 ,判断关木通复方 (当归四逆加吴茱萸生姜汤颗粒剂KM -38旧方 )是否有肾毒性 ,以便指导临床安全用药。 [方法 ]监测经辨证在药典剂量 ( <6g)下短期 ( <6 0d)服用关木通复方 (当归四逆加吴茱萸生姜汤颗粒剂KM -38旧方 )的病人 ,于服药前后体重、血压、血红蛋白及肾功能特别是尿中低分子量蛋白的变化。 [结果 ]服药前后患者体重、血压、血红蛋白及肾功能等各项指标均未见明显异常 (P >0 .0 5 )。 [结论 ]关木通的肾毒性可能与超量、长期、不辨证服用有关。更多还原

【Abstract】 To investigate the possible nephrotoxicity of Compound Decoction of Caulis Aristolochiae Manshuriensis (CDCAM). Body weight, blood pressure, hemoglobin and renal functions, especially of urinary low-molecular weight protein in patients were observed before and after a short-term (<60d) administration of CDCAM in the dose of less than 6g on the basis of TCM syndrome differentiation.No significant difference of the above indexes were found before and after the administration(P> 0.05 ).[Conclusion]The nephrotoxicity of Caulis Aristolochiae Manshuriensis may be associated with the long-term over-dose administration and without TCM syndrome differentiation.更多还原