【摘要】 目的 :对人工蛇胆川贝制剂与其同类品的药效学进行对比研究。方法 :参照文献方法 ,观察其在镇咳、祛痰、抗炎及平喘方面的作用。结果 :人工蛇胆及天然蛇胆川贝散均可明显延长小鼠的咳嗽潜伏期及减少其 3min内咳嗽次数 ;促进小鼠呼吸道分泌 ,增加酚红排泌量 ;抑制二甲苯致小鼠耳朵炎症反应 ,降低肿胀度。人工蛇胆川贝液及其天然品均能明显抑制Ach所致的离体豚鼠气管痉挛反应。结论 :人工蛇胆替代天然蛇胆与川贝配伍制成复方制剂是有效的 ,其镇咳、祛痰、抗炎及平喘的功效与其同类天然品相当更多还原

【Abstract】 The preliminary pharmacodynamic studies of the preparation of artificial Fel Serpentis and Bulbus Fritiliariae Cirrhosae and Shedan Chuanbei San (composed of natural Fel Serpentis and Bulbus Fritiliariae Cirrhosae) were reported.The results showed that both of the above preparations could prolong the cough latency and decrease cough frequeucies induced by ammonia within 3 min,promote the excretion of respiratory tract,increase the excretion of phenol red and inhibit auricular edema induced by xylol in mice. Meanwhile, the above two preparations could also inhibit Ach-induced tracheospasm in vitro.Therefore,the replacement of natural Fel Serpentis with the artificial in the preparation of Shedan Chuanbei San is reasonable.更多还原