【摘要】 目的　建立舒张性心力衰竭 (DHF)兔动物模型。方法　采用腹主动脉缩窄法建立兔压力负荷性心肌肥厚动物模型 ,通过超声心动图监测和左心导管检查测定左室舒张末压和松弛时间常数 ,判断是否存在DHF。结果　DHF兔室间隔和左室后壁明显增厚 ,左室舒张末压明显升高 ,松弛时间常数明显延长。结论　提示本研究成功地建立了DHF动物模型 ;并且在动物模型建立的过程中 ,超声心动图为心肌肥厚时左室收缩和舒张功能的监测提供了无创性手段更多还原

【Abstract】 Objective To establish animal model of diastolic heart failure.Methods DHF was produced in rabbits by abdominal aortic coarctation.Systolic and diastolic function was assessed by echocardiography and catheterization during left hypertrophy progression.Results The interventricular septum and left ventricular posterior wall thickness of DHF rabbits were significantly increased compared with sham operated rabbits.Myocardial relaxation was prolonged and left ventricular end diastolic pressure was significant increased in DHF rabbit in 8 weeks obtained through cardiac catheterization,despite normal left ventricular systolic function.Conclusion It is suggesting that rabbit model of DHF was established successfully.Echocardiography is a noninvasive method to access left ventricular diastolic and systolic function during animal model establishment. [更多还原