【摘要】 目的 :研究不同促渗剂对奥沙普秦渗透性的影响。方法 :采用Valia Chien扩散池进行大鼠离体皮肤的体外渗透实验。结果 :1%氮酮、3%氮酮、10 %油酸均具有极显著的促渗作用 (P <0 .0 1) ,5 %油酸具有显著的促渗作用 (P <0 .0 5 ) ,而薄荷油的促渗作用不明显 (P >0 .0 5 ) ,其中以 3%氮酮的促渗效果最好。结论 :奥沙普秦经皮渗透符合零级动力学过程 ,不因促渗剂的加入而改变更多还原

【Abstract】 Objective:To study the effect of osmotic enhancers on the permeability of oxaprozin.Methods:The penetrating rate of oxaprozin to pass the isolated skin of rats was measured by using Valia Chien diffusion cell.Results:1% and 3% azone,and 10% oleic acid possess very remarkable osmotic enhancer’s effect,and 5% oleic acid also has remarkable osmotic enhancer’s effect.3% azone is the best osmotic enhancer in comparison with the others.Conclusion:The transdermal process of oxaprozin fitted to a zero order kinetic mechanism and was not affected by addition of osmotic enhancer. [更多还原