【摘要】 目的 :评价异丁司特缓释胶囊治疗支气管哮喘和慢性喘息性支气管炎的疗效和安全性。方法 :采用双盲双模拟随机平行对照临床试验。试验组 40例 ,口服异丁司特缓释胶囊 10mg ,bid ,疗程 6周。对照组 40例 ,口服曲尼司特胶囊 10 0mg ,tid ,疗程 6周。结果 :试验组总显效率为 6 7.5 % ,总有效率为 90 .0 %。肺功能显著改善 17例 ,中度改善 11例 ,改善 8例。治疗分数明显低于试验前 (P <0 .0 1)。IgE值治疗后比治疗前明显降低 (P <0 .0 1)。上述结果均与对照组相似。试验药物不良反应发生率为 2 7.5 % ,且多为轻度反应 ,并可耐受。结论 :异丁司特缓释胶囊是一种安全有效的治疗支气管哮喘和慢性喘息性支气管炎的药物更多还原

【Abstract】 Objective:To evaluate the efficacy and safety of ibudilast sustained release capsule in treatment of asthma or chronic asthmatic bronchitis.Methods:80 patients with asthma or chronic asthmatic bronchitis were randomly allocated to receive twice daily 10 mg ibudilast sustained release capsule for 6 weeks or three times daily 100 mg tranilast sustained release capsule for 6 weeks.Results:The total significantly effective rate,total effective rate,improvement in lung function and decrease in IgE value obtained were similar in both active and control groups.Conclusion:Ibudilast sustained release capsule is an effective agent for treatment of asthma or chronic asthmatic bronchitis.更多还原