【摘要】 目的 :探讨粘附分子ICAM - 1、VCAM - 1在人肝细胞癌中的表达及其与肝细胞癌侵袭性的关系。方法 :采用免疫组织化学方法 (SABC)探讨二者在正常肝组织、肝海绵状血管瘤和 36例不同侵袭性肝细胞癌中的表达 ,并分析其与HCC侵袭性的关系。结果 :ICAM - 1和VCAM - 1在正常肝组织无表达 ,在 6例肝海绵状血管瘤中仅 1例VCAM - 1呈弱阳性表达 ;在 36例肝细胞癌中 ,ICAM - 1、VCAM - 1分别有 2 5例 (6 9.4% )和2 3例 (6 3 .9% )表达 ,且多数呈强阳性表达 ,明显高于癌旁组织的阳性表达率 (33 .3%和 2 6 .7% )。高侵袭肝癌组 (2 1例 )中分别有 18例 (85 .7% )和 17例 (80 .9% )表达ICAM - 1和VCAM - 1,而非侵袭组仅分别有 7例(4 6 .7% )和 6例 (4 0 .0 % )表达 ,其差异有显著意义 (P <0 .0 5 )。结论 :ICAM - 1、VCAM - 1与肝细胞癌生物恶变及侵袭性具有相关性更多还原

【Abstract】 Objective:To investigate the expression of ICAM-1 and VCAM-1 in hepatocellular carcinoma and correlation with invasiveness.Methods:The expression of ICAM-1 and VCAM-1 In 5 normal liver tissues、5 cases of cavernous hemangioma and 36 cases of HCC was investigated using immunohistochemical staining,which was performed on formalin-fixed and paraffin-embeded material.Results:ICAM-1 and VCAM-1 have no expression in normal liver tissues.The aberrant expression of ICAM-1 was found in 25 cases (69.4%) of HCC and VCAM-1 was found in 23 cases (63.9%).Invasive HCC expressed high ICAM-1 and VCAM-1 than non-invasive ones (85.7% vs 46.7%;80.9% vs 40.0%).The difference was significant (P<0.05).Conclusions:ICAM-1 and VCAM-1 are related with malignant transformation and invasiveness of HCC.High expression of ICAM-1 and VCAM-1 is more frequently seen in high invasive HCC and was one of factors for development of its highly invasive potentials.更多还原